Spectrophotometric Determination of Paracetamol by Diazotization and Coupling Reaction with Anthranilic Acid
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Abstract
This paper concerned with development of a spectrophotometric method for the determination of paracetamol, based on the diazotisation and coupling reaction with anthranilic acid in basic medium, to form an intense yellow coloured, water-soluble and stable azo-dye which shows a maximum absorption at 421nm. Beer’s law is obeyed over the concentration range of 1.0-10 µg/ml; with molar absorptivity of 2.1772×104 L.mol -1.cm-1 and Sandell’s sensitivity index 6.9446 µg.cm-2. The method has been applied successfully for the determination of paracetamol in pharmaceutical formulation.
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Spectrophotometric Determination of Paracetamol by Diazotization and Coupling Reaction with Anthranilic Acid. (2017). Ibn AL-Haitham Journal For Pure and Applied Sciences, 29(2), 409-420. https://jih.uobaghdad.edu.iq/index.php/j/article/view/138
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Chemistry
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How to Cite
Spectrophotometric Determination of Paracetamol by Diazotization and Coupling Reaction with Anthranilic Acid. (2017). Ibn AL-Haitham Journal For Pure and Applied Sciences, 29(2), 409-420. https://jih.uobaghdad.edu.iq/index.php/j/article/view/138