Comparison Study of the Effect of Erlotinib as a Tyrosine Kinase Inhibitor on Electrolyte Levels in Type2 Diabetic and Diabetic Nephropathy

Abstract

Diabetes mellitus can be defined as  a metabolic disorder disease .Complication  of diabetes  are due to diabetic nephropathy .This study was done in vitro to study the effect of different concentrations of erlotinib inhibitor ( tyrosine kinase inhibitor) on electrolyte levels (Mg⁺²,Ca⁺²,Na⁺) in sera of Iraqi patients with  newly diagnosis type2 diabetes and diabetic nephropathy in addition to find the best percentage inhibition for utilizing different concentrations from erlotinib (6.97x10⁻⁷, 9.30x10⁻⁷ ,1.16x10⁻⁶,1.39x10⁻⁶ ,1.62x10⁻⁵ )molar  on electrolyte levels . This study was conducted in The National Diabetes Center, Al-Mustansiriya University - Baghdad and included 150 patients divided into50 patients type 2 diabetic as group (G2) , 50patients diabetic nephropathy as group(G3) and also 50 healthy as control group(G1).The period time for aggregation the blood sampling  was from July to October 2017 . All patients were within (18 to 60) years age. Erlotinib(Tyrosine kinase  inhibitor) affected  on serum Mg ⁺²levels in human as a mild effect and a slight effect on seum Na⁺ and Ca⁺².The best inhibition of erlotinib in concentration (1.62x10⁻5)M for both  serum Na⁺ and Ca⁺² in newly diagnosis diabetes type 2 and diabetic nephropathy.serum  Mg ⁺²levels showed best inhibition in  concentration (9.30x10⁻7)M