Synthesis and Characterization New Schiff Bases,Pyrazole and Pyrazoline Compounds Derived From Acid Hydrazide Containing Isoxazoline Ring

Main Article Content

Nebras M. Jamel
Dhuha F. Hussein
Jumbad H. Tomma

Abstract

The work involves synthesis of new Schiff bases ( [V]a, b and [VI]a, b), pyrazoles[VII]a, b and pyrazolines[VIII]a, b derivatives containing isoxazoline unit starting with chalcones. 4bromoacetophenone was reacted with 4-hydroxybenzaldehyde or 4-hydroxyacetophenone was reacted with 4-bromobenzaldehyde in basic medium to give chalcone by Claisen-Schemidt reaction. The chalcons [I]a, b was reacted with hydroxylamine hydrochloride to form  isoxazolines [II]a, b. which were reacted with ethyl chloro acetate in basic medium to get ester compounds[III]a, b .The condensation new ester[III]a, b with hydrazine hydrate80% yieldedacid hydrazide [IV]a, b.The later compound refluxing  with  4-substituted benzaldehyde in dry benzene to give Schiff bases([V]a, band [VI]a, b)while the reaction of acid hydrazide [IV]a, b with acetylacetone or ethyl aceto acetate to get pyrazole[VII]a, b , pyrazolone[VIII]a, b ,respectively.The synthesized compounds were characterized by melting points, FTIR, mass and 1H NMR spectroscopy(of someof them).

Article Details

How to Cite
Synthesis and Characterization New Schiff Bases,Pyrazole and Pyrazoline Compounds Derived From Acid Hydrazide Containing Isoxazoline Ring. (2017). Ibn AL-Haitham Journal For Pure and Applied Sciences, 27(3), 435-447. https://jih.uobaghdad.edu.iq/index.php/j/article/view/308
Section
Chemistry

How to Cite

Synthesis and Characterization New Schiff Bases,Pyrazole and Pyrazoline Compounds Derived From Acid Hydrazide Containing Isoxazoline Ring. (2017). Ibn AL-Haitham Journal For Pure and Applied Sciences, 27(3), 435-447. https://jih.uobaghdad.edu.iq/index.php/j/article/view/308