Synthesis and Characterization of Some Amides Containing Isoxazoline Ring
Main Article Content
Abstract
This work involves synthesis of amides containing isoxazoline unit starting with
chalcone; 4-[3-(3‾-nitrophenyl)-2-propene- 1-one]-aniline[I]. 4-Aminoacetophenone was
reacted with 3-nitrobenzaldehyde in basic medium giving chalcone [I] by claisen-schemidt
reaction. The chalcone [I] was reacted with hydroxylamine hydrochloride giving isoxazoline
[II] in NaOH basic medium. The amides with structural formula [III]a-h were prepared by the
reaction of amino compounds ; isoxazoline [II] with different acid chlorides in dry pyridine
and using DMF as a solvent at 4
0
C. All the synthesized compounds have been characterized
by melting points , FTIR and
1
HMNR (of compound [III]a) spectroscopy.
Article Details
How to Cite
Synthesis and Characterization of Some Amides Containing Isoxazoline Ring. (2017). Ibn AL-Haitham Journal For Pure and Applied Sciences, 25(3), 254-263. https://jih.uobaghdad.edu.iq/index.php/j/article/view/591
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Section
Chemistry
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How to Cite
Synthesis and Characterization of Some Amides Containing Isoxazoline Ring. (2017). Ibn AL-Haitham Journal For Pure and Applied Sciences, 25(3), 254-263. https://jih.uobaghdad.edu.iq/index.php/j/article/view/591