Synthesis, Characterization and Antibacterial Activity of Some New Five-Seven Membered Rings Attached to Sulfonamide Compounds

Main Article Content

Ismaeel Y. Majeed
Shimaa A. Saoud
Ahmed A. Ahmed
Eman F. Mustafa

Abstract

   This work includes the  synthesis of some new five- seven heterocyclic rings derived from benzenesulfonylhydrazide as starting material. Its condensation with 4-methoxy and 4nitro benzaldehyde gives the Schiff bases (1a,b). Schiff bases were reacted with cyclic anhydrides given  Oxazepine, Thiazepine derivatives(2,3,4 a,b)(seven membered ring) and with 2-mercapto benzoic acid gives thiazine derivatives (6a,b)(six membered ring) finally with thioglycolic acid give thiazolidine ring(five membered ring) scheme(3). The synthesized compounds have been characterized by melting points,FT-IR, 1H-NMR spectroscopy ,13CNMR and Elemental analysis. some of synthesized  compounds were tested for their antibacterial activity against staphylococcus aureus, pseudomonous aureous  and Escherichia coli .The results showed good efficacy against these types of bacteria.

Article Details

How to Cite
Synthesis, Characterization and Antibacterial Activity of Some New Five-Seven Membered Rings Attached to Sulfonamide Compounds. (2017). Ibn AL-Haitham Journal For Pure and Applied Sciences, 27(2), 170-177. https://jih.uobaghdad.edu.iq/index.php/j/article/view/340
Section
Chemistry

How to Cite

Synthesis, Characterization and Antibacterial Activity of Some New Five-Seven Membered Rings Attached to Sulfonamide Compounds. (2017). Ibn AL-Haitham Journal For Pure and Applied Sciences, 27(2), 170-177. https://jih.uobaghdad.edu.iq/index.php/j/article/view/340