Clinical Evidence: The Prolonged Dust Exposure The Disorder In Serum Oxidant - Antioxidant Balance

Abstract

Dust can  be considered as  an  important factor in  environmental

pollution which has a direct eOect on human health. In this study ,we

attempted to eval uate serum oxidant -antiox idant balance in workers dust exposed continuously and also the effect of iron and silicon content in exposed dust on the mentioned balance .The study included tbrcc groups: A group  included 20  workers of  building block factories, B  group included 20 workers in general company of grains production and C group included 15 healthy' subjects which represented control group. !ron and  silicon  contents in  dust samples of  two  studied  regions were measured. Higher levels of iron and silicon were found in A group region compared to B group region. Our results il lustrated a significant elevation in serum  (MDA) l evcl(the  index of  lipid peroxidati on) for A group compared to  Band C  groups. Also, a  significant  decrease in  semm

albumin level was found in A group compared to C group as well as · semm ceruloplasmin level  in A group was found to  be significantly elevated compared to 8 and C grou ps. A negative correlation was found between serum MDA and ser um albumin levels in A and B groups. Also

,positive correlations were found between senun MDA and each of serum ceruloplasmin and daily dust exposure time in A and B groups. These results provide a new conclusion that the iron and silicon content in prol onged exposed dust lead to disorder in serum oxidant - anti oxidant balance.