Remedy Efficiency through Paclitaxel on Rat (Rattus norvegicus) Brain Injury and Risk Premium of N- Diethyl nitrosamine (DEN) Injection
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Abstract
Abstract
The current study deals with the effect of N-Diethylnitrosamine (DEN) induced traumatic brain injury on male albino rats, as well as the outcome results of treatment with paclitaxel nanoparticles for a period of 8 weeks with two-week intervals is the concern of the present study. Mean body weight, as well as brain weight, was considered as the main parameters whereas a detailed immunohistochemical study on rat brain sections was performed. Astrocytic biomarkers for the diagnosis of astrocytes by fibrillary glial acidic protein (GFAP). Neuronal GFAP staining used for various broke sections were forwarded. Comparison and Contrast of all these parameters in all steps of the experiment had been discussed. The efficiency of the treatment was found to be evident. The effect on body weight was significant whereas brain weight results showed insignificant differences. A longer duration of treatment may well reflect more significant results.
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TAO, Z.; SHI, A.; LU, C.; SONG, T.; ZHANG, Z. ; ZHAO, J. Breast cancer: epidemiology and etiology. Cell biochemistry and biophysics, 2015,72, 333-338.
LIM, D. S.; ROH, T. H.; KIM, M. K.; KWON, Y. C.; CHOI, S. M.; KWACK, S. J.; KIM, K.
B.; YOON, S.; KIM, H. S. ; LEE, B.-M. Risk assessment of N-nitrosodiethylamine (NDEA) and N-nitrosodiethanolamine (NDELA) in cosmetics. Journal of Toxicology and Environmental Health, Part A, 2018,81, 465-480.
LI, X.; HE, X.; DONG, Y.; JIA, L. ; HE, Q. Analysis of N-nitrosodiethylamine by ion
chromatography coupled with UV photolysis pretreatment. journal of food and drug analysis, 2016, 24, 311-315.
AFZAL, A.; KANG, J.; CHOI, B.-M. ; LIM, H.-J.. Degradation and fate of N-
nitrosamines in water by UV photolysis. International Journal of Greenhouse Gas Control, 2016, 52, 44-51.
ROY, S. R. ; GADAD, P. C. Effect of β-asarone on diethylnitrosamine-induced hepatocellular carcinoma in rats. Indian Journal of Health Sciences and Biomedical Research (KLEU), 2016,9, 82.
ADEBAYO, O. A.;AKINLOYE, O. ; ADARAMOYE, O. A. Cerium oxide nanoparticles attenuate oxidative stress and inflammation in the liver of diethylnitrosamine-treated mice. Biological Trace Element Research,2020, 193, 214-225.
QIU, P.; SUN, J.; MAN, S.; YANG, H.; MA, L.; YU, P. ; GAO, W.. Curcumin attenuates N-nitrosodiethylamine-induced liver injury in mice by utilizing the method of metabonomics. Journal of agricultural and food chemistry, 2017, 65, 2000-2007.
AQUILINA, N. J.; HAVEL, C. M.; HARRISON, R. M.; HO, K.-F.; BENOWITZ, N. L. ; JACOB III, P. Determination of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) arising from tobacco smoke in airborne particulate matter. Environment International, 2022,158, 106992.
HARSHITA; BARKAT, M. A.; BEG, S.; POTTOO, F. H. ; AHMAD, F. J. Nanopaclitaxel therapy: an evidence based review on the battle for next-generation formulation challenges. Nanomedicine, 2019,14, 1323-1341.
MAMADALIEVA, N. ; MAMEDOV, N. Taxus brevifolia a High-Value Medicinal Plant, as a Source of Taxol. Medicinal and Aromatic Plants of North America. Springer, 2020.
CHUANG, C. H. ; HU, M. L.. Synergistic DNA damage and lipid peroxidation in cultured human white blood cells exposed to 4‐(methyl‐nitrosamino)‐1‐(3‐pyridyl)‐1‐butanone and ultraviolet A. Environmental and molecular mutagenesis, 2006, 47, 73-81.
IMOSEMI, I.; ADEKANMBI, A. ; ATIBA, F.. Telfairia occidentalis Leaf Extract Protects the Cerebellar Cortex against Cisplatin-Induced Oxidative Damage in Wistar Rat. Archives of Basic and Applied Medicine, 2020, 8, 55-60.
SHEHATA, T. M. ; ELSEWEDY, H. S.. Paclitaxel and Myrrh oil Combination Therapy for Enhancement of Cytotoxicity against Breast Cancer; QbD Approach. Processes, 2022,10, 907.
ZHU, L.; CHEN, L. 2019. Progress in research on paclitaxel and tumor immunotherapy. Cellular & haref, A.Y.; Hamdi, B.A.; Alnajar, Z.A. Histopathological aspects of co-administration of dexamethasone and diclofenac sodium on male albino rats. Zanco Journal of Medical Sciences (Zanco J Med Sci) 2020 , 24(2), 236-245.
GFAP positivity in neurons following traumatic brain injuries
Sharef. A.Y.; Hamdi. B.A.; Alnajar, Z.A. Histopathological aspects of co-administration
of dexamethasone and diclofenac sodium on male albino rats. Zanco Journal of Medical Sciences Zanco J Med Sci, 2020, 24(2), 236-245.
Roshangar, L.; Hamdi, B.A.; Khaki, A.A.; Rad, J.S.; Soleimani-Rad, S. Effect of low- frequency electromagnetic field exposure on oocyte differentiation and follicular development. Advanced biomedical research, 2014, 3. GFAP positivity in neurons following traumatic brain injuries
Petkov, D.I.; et al., Characterization of heart macrophages in rhesus macaques as a model to study cardiovascular disease in humans. Journal of p. 1255.https://doi.org/10.1002/JLB.1A0119-017R PMID: 31287581
Exosome Derived from Human Neural Stem Cells Improves Motor Activity and Neurogenesis in a Traumatic Brain Injury Model. Abedi M, Hajinejad M, Atabi F, Sahab-Negah S. Biomed Res Int. 2022, Aug 12:2022:6409346. doi: 10.1155/2022/6409346. eCollection 2022.
BILGIÇ, S., ÖZGÖÇMEN, M. & OZER, M. K.. Thymoquinone ameliorates amikacin induced oxidative damage in rat brain tissue. Biotechnic & Histochemistry, 2022,1-8.
GLANTZ, M. J., CHOY, H., KEARNS, C. M., MILLS, P. C., WAHLBERG, L. U., ZUHOWSKI, E. G., CALABRESI, P. & EGORIN, M. J. Paclitaxel disposition in plasma and central nervous systems of humans and rats with brain tumors. JNCI: Journal of the National Cancer Institute, 1995,87, 1077-1081.
Sehba FA, Ding WH, Chereshnev I, Bederson JB (1999) Effects of S-nitrosoglutathione on acute vasoconstric tion and glutamate release after subarachnoid hemor rhage. Stroke 30:1955-61
OWUMI, S.. Cissampelos capensis and Pleiocarpa pycantha Extracts Protect against N-nitrosodiethylamine-induced Hepatotoxicity in Wistar. Archives of Basic and Applied Medicine, 2019, 7, 57–65-57–65.
Sofroniew, MV.;Vinters, HV., Astrocytes: biology and pathology. Acta Neuropathol ,2010,119,7-35. https://doi.org/10.1007/ S00401-009-0619-8
Gimenez YRM; Langa, F.; Menet, V.; Privat A Comparative anatomy of the cerebellar cortex in mice lacking vimentin, GFAP, and both vimentin and GFAP ,2000, Glia 31:69-83. https://doi.org/10. 1002/(sici)1098-1136(200007)31:1<69::aid-glia70>3.0.co;2-w 38. Liedtke W
HUANG, X.-J.; GLUSHAKOVA, O.; MONDELLO, S.; VAN, K.; HAYES, R. L. ; LYETH, B. G.. Acute temporal profiles of serum levels of UCH-L1 and GFAP and relationships to neuronal and astroglial pathology following traumatic brain injury in rats. Journal of neurotrauma, 2015, 32, 1179-1189.
Trautz, F.;Franke, H.; Bohnert, S.; et al. Survival-time dependent increase in neuronal IL-6 and astroglial GFAP expression in fatally injured human brain tissue. Sci Rep. 2019;9:11771. doi: 10.1038/s41598-019-48145-w -DOI-PMC- PubMed
Li DR; Ishikawa T; Zhao, D. et al ,Histopathological changes of the hippocampus neurons in brain injury. Histol Histopathol ,2009, 24,1113-1120. https://doi.org/10.14670/HH-24.1113.