Reproductive Dysfunction in Women with PCOS: A Review Article

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Published: Apr 20, 2024
DOI: https://doi.org/10.30526/37.2.3246
Keywords:
Polycystic ovary syndrome, obesity, infertility, insulin resistant, metabolic disturbance.

Main Article Content

Abdulrahman R. Mahmood
Department of Chemistry, College of Education for Pure Sciences Ibn-Al-Haitham, University of Baghdad, Baghdad, Iraq.
https://orcid.org/0000-0003-2982-9149
Mohamad R. Abdullah
Department of Chemistry, College of Education for Pure Science Ibn-Al Haitham, University of Baghdad, Baghdad, Iraq.
https://orcid.org/0000-0001-6712-7119
Husam S. Khalaf
Department of Chemistry, College of Education for Pure Science Ibn-Al Haitham, University of Baghdad, Baghdad, Iraq.
https://orcid.org/0000-0003-3932-3483
Waled Abdo Ahmed
Department of Chemistry, Faculty of Education, Dhamar University, Dhamar, Yemen.
https://orcid.org/0000-0001-8185-833X

Abstract

Polycystic ovary syndrome (PCOS) is a significant cause of infertility due to ovulation dysfunction in women of childbearing age. Although the pathogenesis of PCOS is still not clear, many studies have shown that many factors within the ovary promote infection. With this syndrome, the disruption of the natural monthly ovulation process causes an imbalance in the body's hormones, and the high level of insulin in the body and the blood sugar imbalance leads to the occurrence of hyperandrogenism, which is the main factor for the occurrence of pathogens, in addition to genetic factors, if any. This study aims to identify this disease and its most important causes, symptoms, and modern treatments to prevent and get rid of it. Polycystic ovarian syndrome is diagnosed based on the presence of anovulation associated with biochemical or clinical hyperandrogenism, and the new diagnostic criteria at the Rotterdam Conference 2003 are the basis for the diagnosis now. Obesity, infertility, irregular menstruation, recurrent miscarriage, and hirsutism are essential factors that must be treated to have a healthy pregnancy.

Article Details

How to Cite
[1]
Abdulrahman R. Mahmood et al. 2024. Reproductive Dysfunction in Women with PCOS: A Review Article. Ibn AL-Haitham Journal For Pure and Applied Sciences. 37, 2 (Apr. 2024), 231–241. DOI:https://doi.org/10.30526/37.2.3246.
Issue
Vol. 37 No. 2 (2024)
Section
Chemistry
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References

Legro, R.S.; Arslanian, S.A.; Ehrmann, D.A.; Hoeger, K.M.; Murad, M.H.; Pasquali, R.; Welt, C.K. Diagnosis and treatment of polycystic ovary syndrome: An endocrine society clinical practice guideline. J Clin Endocrinol Metab 2013, 98(12),4565-4592. https://doi:10.1210/jc.2013-2350.

Sirmans, S.M.; Pate, K.A. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin Epidemiol 2013, 6,1-13. https://doi:10.2147/clep.s37559.

del Tirado, F.J.C.; Ortega, A.J.M.; Del Tirado, R.A.C. Guía de práctica clínica de síndrome de ovario poliquístico. Arch Med 2014, 10(23),1-14. https://doi:10.3823/1216.

Ganong, W.F. Review of medical physiology. In; California, 1995, 310–320.

https://tulisanfajri.files.wordpress.com/2014/11/ganong-review-of-medical-phys.pdf.

Markovic, N.; Markovic O. What every woman should know about cervical cancer. Cancer 2016, 1–18. https://doi:10.1007/978-94-017-7560-1.

Williams, T.; Mortada, R.; Porter, S. Diagnosis and treatment of polycystic ovary syndrome. Am Fam Physician 2016, 94(2),106-113. https://doi:10.3803/jkes.2007.22.4.252.

Syusyuka, V.G.; Sergienko, M.Y.; Makurina, G.I.; Yershova, O.A.; Chornenka, A.S. Polycystic ovary syndrome: Clinical and pathogenetic aspects of a multidisciplinary problem. Reprod Heal Woman 2021. https://doi:10.30841/2708-8731.2.2021.232513.

Ruiz, T.F.R.; Grigio, V.; Ferrato, L.J.; de Souza, L.G.; Colleta, S.J.; Amaro, G.M.; Góes, R.M.; Vilamaior, P.S.L.; Leonel, E.C.R.; Taboga, S.R. Impairment of steroidogenesis and follicle development after bisphenol A exposure during pregnancy and lactation in the ovaries of mongolian aerbils Aged females. Molecular and Cellular Endocrinology 2023, 566–567. https://doi: 10.1016/j.mce.2023.111892.

Zeng, X.; Huang, Y.; Zhang, M.; Chen, Y.; Ye, J.; Han, Y.; Ma, D.; Zheng, X.; Yan, X.; Liu, C. Anti-müllerian hormone was independently associated with central obesity but not with general obesity in women with PCOS. Endocr Connect 2022, 11(1),e210243. https://doi:10.1530/EC-21-0243.

Steril, F. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group. Rotterdam 2004, 19(1),41-47. https://doi: 10.1093/humrep/deh098.

Cunningham, P. Pathophysiology, diagnosis and treatment of polycystic ovary syndrome. Nurs Stand 2017, 31(39),44-51. https://doi:10.7748/ns.2017.e10595.

Neven, A.C.H.; Laven, J.; Teede, H.J.; Boyle, J.A. A summary on polycystic ovary syndrome: Diagnostic criteria, prevalence, clinical manifestations, and management according to the latest international guidelines. Semin Reprod Med 2018, 36(1),5-12. https://doi:10.1055/s-0038-1668085.

Bulsara, J.; Patel, P.; Soni, A.; Acharya, S. A review: Brief insight into polycystic ovarian syndrome. Endocr Metab Sci 2021, 3,100085. https://doi:10.1016/j.endmts.2021.100085.

Pfieffer, M.L. Polycystic ovary syndrome: An update. Nursing (Lond) 2019, 49(8),34-40.

https://doi:10.1097/01.NURSE.0000569748.65796.d1.

Brassard, M.; AinMelk, Y.; Baillargeon, J.P. Basic infertility including polycystic ovary syndrome. Med. Clin. North Am 2008, 92(5),1163-1192.https://doi: 10.1016/j.mcna.2008.04.008.

Lanzo, E.; Monge, M.; Trent, M. Diagnosis and management of polycystic ovary syndrome in adolescent girls. Pediatr Ann 2015, 44(9),e223-230. https://doi:10.3928/00904481-20150910-10.

Ignatov, A.; Ortmann, O. Endocrine risk factors of endometrial cancer: Polycystic ovary syndrome, oral contraceptives, infertility, tamoxifen. Cancers (Basel) 2020, 12(7),1766.

https://doi:10.3390/cancers12071766.

Leutner, M.; Göbl, C.; Wolf, P.; Maruszczak, K.; Bozkurt, L.; Steinbrecher, H.; Just-Kukurova, I.; Ott, J.; Egarter, C.; Trattnig, S.; Kautzky-Willer, A . Pericardial fat relates to disturbances of glucose metabolism in women with the polycystic ovary syndrome, but not in healthy control subjects. Int J Endocrinol 2018, 2018, 5406128. https://doi:10.1155/2018/5406128.

Solomon, C.G. The epidemiology of polycystic ovary syndrome: Prevalence and associated disease risks. Endocrinol Metab Clin North Am 1999, 28(2),247-263. https://doi:10.1016/S0889-8529(05)70069-4.

Cutler, D.A.; Pride, S.M.; Cheung, A.P. Low intakes of dietary fiber and magnesium are associated with Insulin Resistance and hyperandrogenism in polycystic ovary syndrome: A Cohort Study. Food Sci Nutr 2019, 7(4),1426-1437. https://doi:10.1002/fsn3.977.

Lewandowski, K.C.; Skowrońska-Jóźwiak, E.; Łukasiak, K.; Gałuszko, K.; Dukowicz, A.; Cedro, M.; Lewiński, A. How much insulin resistance in polycystic ovary syndrome? comparison of HOMA-IR and insulin resistance (Belfiore) index models. Arch Med Sci 2019, 15(3),613-618.

https://doi:10.5114/aoms.2019.82672.

Cena, H.; Chiovato, L.; Nappi, R.E. Obesity, polycystic ovary syndrome, and infertility: A new avenue for GLP-1 receptor agonists. J Clin Endocrinol Metab 2020, 105(8),e2695-e2709.

https://doi: 10.1210/clinem/dgaa285.

Ebersole, A.M.; Bonny, A.E. Diagnosis and treatment of polycystic ovary syndrome in adolescent females. Clin Obstet Gynecol 2020, 63(3),544-552. https://doi:10.1097/GRF.0000000000000538.

Fornes, R.; Simin, J.; Nguyen, M.H.; Cruz, G.; Crisosto, N.; van der Schaaf, M.; Engstrand, L.; Brusselaers, N. Pregnancy, perinatal and childhood outcomes in women with and without polycystic ovary syndrome and metformin during pregnancy: A nationwide population-based study. Reprod Biol Endocrinol 2022, 20(1),30. https://doi:10.1186/s12958-022-00905-6.

Hazlehurst, J.M.; Singh, P.; Bhogal, G.; Broughton, S.; Tahrani, A.A. How to manage weight loss in women with obesity and PCOS seeking fertility? Clinical Endocrinology 2022, 97(2),208–216. https://doi:10.1111/cen.14726.

Conlon, J.L.; Malcolm, S.; Monaghan, M. Diagnosis and treatment of polycystic ovary syndrome in adolescents. JAAPA 2021, 34(10),15-22. https://doi:10.1097/01.JAA.0000791468.37054.5d.

Carreau, A.M.; Baillargeon, J.P. PCOS in adolescence and type 2 diabetes. Curr Diab Rep 2015, 15(1), 564. https://doi.org/10.1007/s11892-014-0564-3.

Barber, T.M.; Hanson, P.; Weickert, M.O.; Franks, S. Obesity and polycystic ovary syndrome: Implications for pathogenesis and novel management strategies. Clin Med Insights Reprod Heal 2019, 13, 117955811987404. https://doi:10.1177/1179558119874042.

Parker, J. Emerging concepts in the pathogenesis and treatment of polycystic ovary syndrome. Curr Womens Health Rev 2016, 10(2),107-112. https://doi:10.2174/1573404811666150214004706.

Wong, J.M.W.; Gallagher, M.; Gooding, H.; Feldman, H.A.; Gordon, C.M.; Ludwig, D.S.; Ebbeling, C.B. A randomized pilot study of dietary treatments for polycystic ovary syndrome in adolescents. Pediatr Obes 2016, 11(3),210-220. https://doi:10.1111/ijpo.12047.

Rosenfield, R.L. Perspectives on the international recommendations for the diagnosis and treatment of polycystic ovary syndrome in adolescence. J Pediatr Adolesc Gynecol 2020, 33(5),445-447.

https://doi: 10.1016/j.jpag.2020.06.017.

Gnanadass, S.A.; Prabhu, Y.D.; Gopalakrishnan, A.V. Association of metabolic and inflammatory markers with polycystic ovarian syndrome (PCOS): An update. Arch Gynecol Obstet 2021, 303(3),631-643. https://doi: 10.1007/s00404-020-05951-2.