Synthesis and Antibacterial Activity of Some Novel Schiff S-Bases Compounds Containing Oxadiazole Ring

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J. H. Tomma A. H. Raheema I. H. Rouil

Abstract


Condensation of 4-methoxybenzoyl hydrazine with 4- aminobenzoic acid in the presence of POCl3 gave the oxadiazole derivative [III] .This compound was demethylated with aluminium chloride to give series of 2- (4-hydroxy phenyl)-5-(4-amino phenyl)
1,3,4-oxadiazole [IV]. Series of Schiff s bases [V]n were synthesized by the condensation of compound [IV] with 4-n-alkoxy benzaldehyde in the presence of glacial acetic acid. Condensation of compounds [VI]n.  with adipoyl chloride in dry pyridine leads to the formation of a new homologous series [VI]n. The structures of the synthesized compounds were confirmed by physical and spectral means The new compounds [VI]n have been screened for their antibacterial activities . The results showed considerable antibacterial
activity against Escherichia Coli (G-),but did not show any antibacterial activity against Staphylococcus aureus (G+)

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How to Cite
TOMMA, J. H.; RAHEEMA, A. H.; ROUIL, I. H.. Synthesis and Antibacterial Activity of Some Novel Schiff S-Bases Compounds Containing Oxadiazole Ring. Ibn AL- Haitham Journal For Pure and Applied Science, [S.l.], v. 18, n. 1, p. 41-49, june 2019. ISSN 2521-3407. Available at: <http://jih.uobaghdad.edu.iq/index.php/j/article/view/2194>. Date accessed: 26 aug. 2019.
Section
Chemistry