Synthesis and Characterization of Novel Schiff Bases Containing Isoxazoline or Pyrazoline Unit

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M. S. Khazaal J. H. Tomma

Abstract

  This work involves synthesis of novel Schiff bases derivatives contining isoxazoline or pyrazoline units starting with chalcons . 4-Aminoacetophenone was react with pnitrobenzaldehyde or p-chlorobenzaldehyde in basic medium giving chalcones [I]a,b by claisenschemidt reactions. The chalcones [I]a,b were reacted with hydroxylamine hydrochloride giving isoxazolines [II]a,b  in basic medium. The chalcone [I]a could also reacted with hydrazine hydrate to give pyrazolines [III]a  . The novel Schiff bases with structural formula [VIII]n , [IX]n , [X]m and [XI]m were prepared by the reaction of amino compounds ; isoxazoline [II]a,b and pyrazolines [III]a with monoaldehydes [VI]n and dialdehydes [VII]m , respectively in dry benzene using drops of glacial acetic acid as a catalyst with reflux . All the synthesized compounds have been characterized by melting points , FTIR , UV-Vis and 1HMNR (of some of theme) spectroscopy

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How to Cite
KHAZAAL, M. S.; TOMMA, J. H.. Synthesis and Characterization of Novel Schiff Bases Containing Isoxazoline or Pyrazoline Unit. Ibn AL- Haitham Journal For Pure and Applied Science, [S.l.], v. 24, n. 2, may 2017. ISSN 2521-3407. Available at: <http://jih.uobaghdad.edu.iq/index.php/j/article/view/767>. Date accessed: 18 sep. 2019.
Section
Chemistry