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The present study is designed to reveal the effect of Voltarin drug on some genetic indicators such as mitotic index(MI) of bone marrow cells and chromosome aberrations(CA) .The Voltarin is one of non Steroidal Anti-inflammation drug .Three concentrations of Voltarin were used 1.6 , 2 , 2.5 mg/kg Albino mices (Mus musculus) were injected for 7 days then mitotic index (MI) was counted and chromosomal aberrations of bone marrow cells . The results could be summarized as follows : 1-The doses (1.6,2) mg/Kg showed no negative effects on mitotic index of bone marrow cells as compared with the control . 2- The dose 2.5 mg/Kg showed a significant difference as compared with the control and the other groups by decreasing mitotic index. The decrease was due to the increase of concentration . 3-Voltarin drug did not show chromosomal aberrations in the light of the doses used .