The Effect of Rifadin Drug on Lipids Metabolism of Rabbits

Abstract

  The aim of this study was intended to study the effect of rifadin drug on lipids metabolism  in the blood of the rabbits .Eight rabbits were used in the experiment ,they were divided into two groups ,first group(control group ) was administrated with 15mg/ml /day normal saline for 35 days ,while the second group (treated group )was administrated with (15/mg /kg/day) for 35 days of rifadin( capsule 300mg/kg).This study examined the influences of rifadin drug on the concentration of cholesterol  , triglycerides , HDL ,LDL and  VLDL in rabbits sera .The result showed that there were no significant  increased (p>0.05) in cholesterol concentration in rifadin  treated group compared with control group ,and there were no significant increase (p>0.05)in LDL  and HDL concentration in rifadin treated group compared with control group ,where the result showed that there was a significant decrease (p<0.05)in triglycerides and VLDL concentration in rifadin treated group compared with  control group .     It was concluded that the rifadin drug  has a negative effect produced dysfunction on lipids metabolism in blood.