Using of Third and Fourth Order Derivative Spectra to Simultaneous Determination of Olanzapine and Ephedrine in Its Pure and Pharmaceutical Formulations

Main Article Content

Mumin F. Hamad Al-Samarrai
Imad T. Hanoon
Diana A. Shakir
Khalaf F. Al-Samarrai
Sarmad B. Dikran

Abstract

 Two new simultaneous spectrophotometric methods for determination of Olanzapine and Ephedrine depend on third (D3) and fourth (D4) derivative of zero spectrum of two drugs were developed. The peak – to- base line, peak to peak and area under peak were found proportional with concentration of the drugs up to (4-24 µg/ml-1) at known experimental wavelengths. The results showed that the method was precise and accurate through  RSD% (0.5026-4.0273),( 0.2399 6.9888) and  R.E %(-2.3889-0.8333) ,) -2.9444-0.2273) while the LOD (0.0057-  0.8510 μg.ml-1), ( 0.0953-0.9844 μg.ml-1) and LOQ (0.0173- 2.5788μg.ml-1),( 0.5774-2.9829 μg.ml-1) were found for the two drugs respectively. The methods were applied ide to the determination of Olanzapine and Ephedrine in pharmaceutical preparations successfully.

Article Details

How to Cite
Al-Samarrai, M. F. H., Hanoon, I. T., Shakir, D. A., Al-Samarrai, K. F., & Dikran, S. B. (2017). Using of Third and Fourth Order Derivative Spectra to Simultaneous Determination of Olanzapine and Ephedrine in Its Pure and Pharmaceutical Formulations. Ibn AL- Haitham Journal For Pure and Applied Sciences, 30(1), 366–375. Retrieved from https://jih.uobaghdad.edu.iq/index.php/j/article/view/1085
Section
Chemistry