Spectrophotometric Determination of Rantidine-HCl in Pharmaceutical Formulations

Main Article Content

A. S. Hammodi

Abstract

Spectrophotometric  methods  were  developed   for    the determination of rantidine-HCl in pharmaceutical tablets. These methods were based on the reaction of DDQ and p-chloranil with rantidine-HCl, resulting in the formation of an orange-red and purple colored products which are quantified spectrophotometrically at 460 and 540nm in DDQ and p-chloranil, respectively. A graph of absorbance versus concentration show that Beer’s law is obeyed in a concentration ranges of 20-160 and (30-120)ï­g/ml with molar absorptivities of 2.631 x 103 and 1.052 x 103l .mol-1-cm-1 for DDQ and  p-chloranil, respectively. The optimum conditions for  color development  are described and  the  proposed  methods  were  applied   satisfactory  to pharmaceutical preparations.

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How to Cite
Spectrophotometric Determination of Rantidine-HCl in Pharmaceutical Formulations. (2017). Ibn AL-Haitham Journal For Pure and Applied Sciences, 22(2). https://jih.uobaghdad.edu.iq/index.php/j/article/view/1244
Section
Chemistry

How to Cite

Spectrophotometric Determination of Rantidine-HCl in Pharmaceutical Formulations. (2017). Ibn AL-Haitham Journal For Pure and Applied Sciences, 22(2). https://jih.uobaghdad.edu.iq/index.php/j/article/view/1244