Spectrophotometric Determination of Paracetamol by Diazotization and Coupling Reaction with Anthranilic Acid

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Mohammed S. Abdul- Raheem
Khalaf F. Alsamarrai
Sarmad B. Dikran

Abstract

This paper concerned with development of a spectrophotometric method for the determination of paracetamol, based on the diazotisation and coupling reaction with anthranilic acid in basic medium, to form an intense yellow coloured, water-soluble and stable azo-dye which shows a maximum absorption at 421nm. Beer’s law is obeyed over the concentration range of 1.0-10 µg/ml; with molar absorptivity of 2.1772×104 L.mol -1.cm-1 and Sandell’s sensitivity index 6.9446 µg.cm-2. The method has been applied successfully for the determination of paracetamol in pharmaceutical formulation. 

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How to Cite
[1]
Abdul- Raheem, M.S. et al. 2017. Spectrophotometric Determination of Paracetamol by Diazotization and Coupling Reaction with Anthranilic Acid. Ibn AL-Haitham Journal For Pure and Applied Sciences. 29, 2 (Mar. 2017), 409–420.
Section
Chemistry

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