Toxicological and Immunological Effects o·f th.e Insecticide Diazinon in Male Albino Mice
Abstract
This st4dy has been ccil'nd·ucted· to ·shed a1ight 00: the
tox:icologital ®d irmm.J,nological effects.of the insectiCide Diaziuon
on male albino mice.
In order to determine the dose whiCh should be ut\lized in he
chrqn:ic exposure study, the LD:so valubas established which rea.ched
58 mg l kg of b0dy weight . Various parameters were· utHizea in
- evaluatitig'the effects of tb:e.·ins.ecticide in fo.ut Weeks ami ig}1t weeks
..p,ost ora.l - e.xposure l'lsing the concentrations 5, lb- l.5 · mg I kg body
- W.eight. Resu}Js sh Jwed an.·in.e:Eeasc in the ni.r!J!ber ofplague.s , which was not statistically sigpific(l_nt a,fte.r twenty eight dayof ex.p(rs:ure to the insecticide at the concentration 5 ppm.
The passive ha:emaglutination· sh.owed a .Significant decrease · in
tib·ody titer at ( p oo I ) post exposure peri0ds. (28,56 d) utilhing
the tlfree variops conc ntrati'ons.
ResuJ.ts·of Arthus ttist indicjlte.d a decline in j.ts valu(} but 'it was riot statiSti<;ally significant afh.tt: 28 and 56 d_ ys pf -exposure to· the. Ci?PI:tcenttatiun. 5pf111l, a!ldt. als_p qf'tr 2.8 days of exposure to the. concentration, tO ppm.
A significant dec.reas.e was noticed at (p 'S ·Q,05) after 56 day§
of exposure to the ooncentratiqp 1@ _ppm Sintilar effect was ::;hoWrt
when animals were exposed to the concentr tion 15ppm after 2·8' and
56 'days. .
Result of delayed type hypersensitiv{ty test showed a signuic.ant decrease at ( ,p· o.OI) .after 28 . and 56 days :of expesute to· the concenttatio11 10 ppm, an<,l aft(!r. 56 day.s of ·exposure- .to. the concentration 15 ppm .
