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Several new derivatives of 1, 2, 4-triazoles linked to phthalimide moiety were synthesized through following multisteps. The first step involved preparation of 2, 2-diphthalimidyl ethanoic acid  via reaction of two moles of phthalimide with dichloroacetic acid. Treatment of the resulted imide with ethanol in the second step afforded 2,2-diphthalimidyl ester which inturn was introduced in reaction with hydrazine hydrate in the third step ,producing the corresponding hydrazide derivative .The synthesized hydazide was introduced in different synthetic paths including treatment with carbon disulfide in alkaline solution then with hydrazine hydrate to afford the new 1,2,4-triazole .Reaction of compound  with different aldehydes produced a new Schiff base derivatives[11,12] .Reaction of derivative  with different aldehydes produced a new derivatives [5-8].All the synthesized compounds have been characterized by melting points ,FTIR ,1HNMR(some of them ) and mass spectroscopy of compound . Derivatives [5, 6, 7, 10, 11, 12] were tested against inhibition of E-coli, staphyloccus aureus and were all found to be active. Schem1,2 illustrated the reaction steps.
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