Solvent -Free One -Pot Multicomponent, Synthesis, Characterization and Anti-bacterial activity, of some 2substituted-3-cyano-Pyridine Derivatives

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Zakaria H. Aiube
Muna S. Al-rawi
Ahmed K. Ebrahem

Abstract

           Solvent- free thermal heating, one-pot condensation of acetophenone, ethyl cyanoacetate or malononitrle and substituted Aromatic aldehyde, ammonium acetate give, 2oxo-3-cyano-4-substituted Aryl-6-phenyl pyridine [I]a-h , or  2-amino-3-cyano-4-substituted Aryl-6-phenyl pyridine derivatives[II]a-f , respectively.              Treatment of compounds 2-oxo-3-cyano-4-substituted Aryl-6-phenyl pyridine with phosphorous penta sulphide (P2S5), give 2-thioxo-3-cyano-4-substituted Aryl-6-phenyl pyridine derivatives[III]a-c .             All prepared compounds are characterized by, C.H.N.S-elmental analysis, melting points, FTIR-and1H-NMR-spectral analysis .              Antibacterial examination of synthesized compounds [I]a-c , [II]a-c  and  [III]a-c against five types of, (G-) and (G+) bacterial  . in  comparison with common  antibiotic like  Ampicillin, Amoxicilin and Lincomycin the result shows 2-thioxo-3-cyano-4-substituted Aryl-6-phenyl pyridine derivatives are more reactive than 2-oxo-3-cyano pyridine derivatives or 2-amino-3-cyano pyridine derivatives .

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How to Cite
Aiube, Z. H., Al-rawi, M. S., & Ebrahem, A. K. (2017). Solvent -Free One -Pot Multicomponent, Synthesis, Characterization and Anti-bacterial activity, of some 2substituted-3-cyano-Pyridine Derivatives. Ibn AL- Haitham Journal For Pure and Applied Sciences, 28(2), 126–135. Retrieved from https://jih.uobaghdad.edu.iq/index.php/j/article/view/182
Section
Chemistry