Analytical Methods for Determination of Ketoprofen Drug: A review

Main Article Content

Jasim Shamar
Sumayha Abbas
Zahra Abbas

Abstract

Ketoprofen has recently been proven to offer therapeutic potential in preventing cancers such as colorectal and lung tumors, as well as in treating neurological illnesses. The goal of this review is to show the methods that have been used for determining ketoprofen in pharmaceutical formulations. Precision product quality control is crucial to confirm the composition of the drugs in pharmaceutical use. Several analytical techniques, including chromatographic and spectroscopic methods, have been used for determining ketoprofen in different sample forms such as a tablet, capsule, ampoule, gel, and human plasma. The limit of detection of ketoprofen was 0.1 ng/ ml using liquid chromatography with tandem mass spectrometry, while it was 0.01- 0.30 µg/ ml using high performance liquid chromatography and 0.00004 - 0.436 µg/ ml, 0.82 µg/ ml, 1.0  µg/ ml, 10  µg/ ml and 208.5 - 237.6  µg/ ml  using flow injection, electrokinetic chromatography, capillary electrophoresis, gas chromatography-flame ionisation detection and derivative infrared spectroscopy respectively.

Article Details

How to Cite
Analytical Methods for Determination of Ketoprofen Drug: A review. (2022). Ibn AL-Haitham Journal For Pure and Applied Sciences, 35(3), 76-82. https://doi.org/10.30526/35.3.2842
Section
Chemistry

How to Cite

Analytical Methods for Determination of Ketoprofen Drug: A review. (2022). Ibn AL-Haitham Journal For Pure and Applied Sciences, 35(3), 76-82. https://doi.org/10.30526/35.3.2842

References

Gentili, A. Determination of non-steroidal anti-inflammatory drugs in environmental samples by chromatographic and electrophoretic techniques. Analytical and Bioanalytical Chemistry. 2007,387(4),1185–202.

Kormosh, Z.; Hunka, I.; Basel, Y. Spectrophotometric determination of ketoprofen and its application in pharmaceutical analysis. Acta Poloniae Pharmaceutica - Drug Research. 2009,66(1),3–9.

Dandić, A.; Rajkovača, K.; Jozanović, M.; Pukleš, I.; Széchenyi, A,; Budetić, M. et al. Review of characteristics and analytical methods for determination of indomethacin. Reviews in Analytical Chemistry. 2022,41(1),34–62.

Dvořák, J.; Hájková, R.; Matysová, L.; Nováková, L.;Koupparis, MA.; Solich, P. Simultaneous HPLC determination of ketoprofen and its degradation products in the presence of preservatives in pharmaceuticals. Journal of Pharmaceutical and Biomedical Analysis. 2004,36(3),625–9.

Zafar, F.;Shoaib ,MH.; Naz, A.; Yousuf, RI.; Ali, H. Determination of Ketoprofen in Human Plasma by RP-HPLC. American Journal of Analytical Chemistry. 2013,04(05),252–7.

Basan, H,; Eda, S.; Ozl, C,; Ertas, N, G G. Quantitative determination of ketoprofen in gels and ampules by using flow-injection UV spectrophotometry and HPLC. 2005,39,606–11.

Hassan, AA.; Shantier, SW.; Gad-kariem, EA. Method and validation of UV-visible spectrophotometric method for estimation of ketoprofen in capsule and tablet dosage. Indo American Journal of Pharmaceutical Research. 2019,9(01),1865–70.

Eid, M.; Talaat, W. Kinetic Spectrophotometric Method For The Determination of Ketoprofen in Pharmaceuticals and Biological Fluids. Structure. 2006,2(4),405–12.

Zhuang, Y,;Song, H. Sensitive determination of ketoprofen using flow injection with chemiluminescence detection. Journal of Pharmaceutical and Biomedical Analysis. 2007;44(3 SPEC. ISS.):824–8.

Šafra, J.; Pospíšilová, M. Separation and determination of ketoprofen, methylparaben and propylparaben in pharmaceutical preparation by micellar electrokinetic chromatography. Journal of Pharmaceutical and Biomedical Analysis. 2008,48(2),452–5.

Tettey-Amlalo RNO, Kanfer I. Rapid UPLC-MS/MS method for the determination of ketoprofen in human dermal microdialysis samples. Journal of Pharmaceutical and Biomedical Analysis. 2009,50(4),580–6.

Farinotti, R.; Mahuzier. G. High‐performance liquid chromatographic determination of ketoprofen in blood and urine. Journal of Pharmaceutical Sciences. 1979,68(4),484–5.

13. Allegrini A, Nuzzo L, Zucchelli M, Scaringi AT, Felaco S, Giangreco D, Pavone

D, Toniato E, Mezzetti A, Martinotti S, Comuzio S, Di Grigoli M. Fast HPLC method

for the determination of ketoprofen in human plasma using a monolithic column and

its application to a comparative bioavailability study in man. Drug Resarch. 2009,59

(3):135–140.

Azeez AM, Fakhre NA. Determination of ketoprofen in tablet dosage forms by derivative IR spectroscopy. Egyptian Journal of Chemistry. 2022;65(1):215–9.

Blanco M, González JM, Torras E, Valverde I. Enantiomeric purity determination of ketoprofen by capillary electrophoresis: Development and validation of the method. Analytical and Bioanalytical Chemistry. 2003;375(1):157–63.

Shafique A, Alothman ZA, Akram S, Akram S, Saad Sohail C, Mushtaq M. An expedient and rapid High-Performance Liquid Chromatographic method for the kinetic study of Ketoprofen. Journal of King Saud University - Science [Internet]. 2020;32(3):2212–8. Available from: https://doi.org/10.1016/j.jksus.2020.02.033

Eichhold TH, Bailey RE, Tanguay SL, Steven H H. Determination of (R)- and (S)-ketoprofen in human plasma by liquid chromatography/tandem mass spectrometry following automated solid-phase extraction in the 96-well format. Journal of Mass Spectrometry. 2000;35(4):504–11.

Hložek T, Bursová M, Čabala R. Fast ibuprofen, ketoprofen and naproxen simultaneous determination in human serum for clinical toxicology by GC-FID. Clinical Biochemistry. 2014;47(15):109–11.

Koppala S, Ranga Reddy V, Anireddy JS. Development and Validation of a Novel Stability-Indicating RP-HPLC Method for the Simultaneous Determination of Related Substances of Ketoprofen and Omeprazole in Combined Capsule Dosage Form. Journal of Chromatographic Science. 2016;54(5):765–75.

Abdel-Hamid ME, Novotny L, Hamza H. Determination of diclofenac sodium, flufenamic acid, indomethacin and ketoprofen by LC-APCI-MS. Journal of Pharmaceutical and Biomedical Analysis. 2001;24(4):587–94.