Study the Interaction Adsorptive Behavior of Sunset Yellow Dye and Loratadine Drug: Kinetics and Thermodynamics Study

Main Article Content

Furat A. Hiawi
Inaam H. Ali


The performance of drug treatment and assessments of different drugs' side effects both can be affected by the interaction between food additives and drugs. Organic compounds such as food colorants dyes are utilized as additives in a wide range of foods. In this study, the adsorption interaction behavior between the colorant food dye sunset yellow (SY) and the drug loratadine was examined. The adsorption procedure is conducted at different drug dosages, various SY dye concentrations, and different temperature (288-318K). The equilibrium data were explained by using Freundlich and Langmuir adsorption isotherms, but Langmuir offering the best fit model. Kinetics adsorptive behavior of sunset yellow on loratadine matched pseudo-second order kinetics. Thermodynamics study show that the process is exothermic, spontaneous and the disorder at the solid-solution interface was proven from the negative entropy (-140.556 J/ K.mol) of adsorption process.

Article Details

How to Cite
Hiawi, F. A. ., & Ali, I. H. . (2023). Study the Interaction Adsorptive Behavior of Sunset Yellow Dye and Loratadine Drug: Kinetics and Thermodynamics Study. Ibn AL-Haitham Journal For Pure and Applied Sciences, 36(1), 186–196.


Silva, M. M; H Reboredo, F. ; Lidon, F.C Food Colour Additives: A Synoptical Overview on Their Chemical Properties, Applications in Food Products, and Health Side Effects. Foods. 2022, 11(3),379.

Smith, J.; Hong-Shum, L. Food Additives Data Book, 2nd ed.; Wiley-Backwell: Hoboken, NJ, USA, 2011; 196–198. ISBN 978-1-405-19543-0.

Luzardo-Ocampo, I.; Ramírez-Jiménez, A.K.; Yañez, J.; Mojica, L.; Luna-Vital, D.A. Technological Applications of Natural Colorants in Food Systems: A Review Foods. 2021, 10, 634.

Kobylewski, S.; Jacobson, M.F.Toxicology of food dyes. Int. J Occup Environ Health. 2012,18 (3),220-246. doi: 10.1179/1077352512Z.00000000034.

Subhashish, D. Bommu, Applications of food color and bio-preservatives in the food and its effect on the human health, Food Chemistry Advances,2022,1.oct.100019.

Bruno, L. ; Cíntia, Z. ; João, A. ; Julio, C. Effects of textile dyes on health and the environment and bioremediation potential of living organisms, Biotechnology Research and Innovation, 2019, 3(2), 275-290.

Kong, Q.; Liu Qun ; M. Miao ; Liu, Y. ; Chen , Q.; Zhao, C., Kinetic and equilibrium studies of the biosorption of sunset yellow dye by alligator weed activated carbon., Treatment. 2017 ,66, 281-290.

Abdel-Aziz, H.M. ; Abdel-Gawad, S.A. Removal of sunset YellowAzo dye using activated carbon entrapped in alginate from aqueous solutions. Open Access J Sci. 2020,4(1):1‒6. DOI: 10.15406/oajs.2020.04.00142.

Mattson, CL.; Tanz, LJ, Quinn, K.; Kariisa, M.; Patelm, P., Davis NL. Trends and Geographic Patterns in Drug and Synthetic Opioid Overdose Deaths — United States, 2013–2019. MMWR Morb Mortal Wkly Rep, 2021, 70,202–207.

National Center for Biotechnology Information. PubChem Compound Summary for CID 3957, Loratadine. Retrieved June 21, 2022.

Rodriguez Amado, J. R. ; Prada, A. L; Duarte, J. L. ; Keita, H. ; da Silva, H. R. ; Ferreira, A. ; Sosa, E. H; Carvalho, J.;Development, stability and in vitro delivery profile of new loratadine-loaded nanoparticles. Saudi pharmaceutical journal: SPJ: the official publication of the Saudi Pharmaceutical Society, 2017, 25(8), 1158–1168. doi: 10.1016/j.jsps.2017.07.008.

Tadele, A.; Adugna, N. ; A comparative study of acidic, basic, and reactive dyes adsorption from aqueous solution onto kaolin adsorbent: Effect of operating parameters, isotherms, kinetics, and thermodynamics, Emerging, Contaminants, 2022, 8, 59-74.

Dey, A.K.; Dey, A. ; Goswami, R. Adsorption characteristics of methyl red dye by Na2CO3-treated jute fibre using multi-criteria decision making approach. Appl Water Sci, 2022, 12, 179.

Filice, S.; Bongiorno, C.; Libertino, S. et al. Structural Characterization and Adsorption Properties of Dunino Raw Halloysite Mineral for Dye Removal from Water. Materials (Base). 2021;14(13):3676. doi: 10.3390/ma14133676.

Lucas, Carvalho., B. Lucas, Carvalho, P.; Maria, C.; Tamara, R. et al, Removal of the synthetic hormone methyltestosterone from aqueous solution using a β-cyclodextrin/silica composite. Journal of environmental chemical engineering, 2019, 7(6):103492-. doi: 10.1016/J.JECE.2019.103492.

Abu-Nada, A. ; Abdala, A.; McKay, G. Isotherm and Kinetic Modeling of Strontium Adsorption on Graphene Oxide. Nanomaterials, 2021,11,2780. 10.3390/nano11112780.

Togue Kamga, F. Modeling adsorption mechanism of paraquat onto Ayous (Triplochiton scleroxylon) wood sawdust. Appl Water Sci, 2019, 9, 1.

Suryakant, A.; Patil, D. Pramod Kumbhar, Bhushan S. Satvekar, Namdev S. Harale, Sagar et al. Adsorption of toxic crystal violet dye from aqueous solution by using waste sugarcane leaf-based activated carbon: isotherm, kinetic and thermodynamic study. Journal of the Iranian Chemical Society , 2022, 19:7, 2891-2906.doiI: 10.1007/s13738-022-02500-3.

Debina, B. ; Eric, S.; Fotio, D.; Arnaud, K. ; Lemankreo, D. ; Rahman, A. Adsorption of Indigo Carmine Dye by Composite Activated Carbons Prepared from Plastic Waste (PET) and Banana Pseudo Stem. Journal of Materials Science and Chemical Engineering, 2020, 8, 39-55. doi: 10.4236/msce.2020.812004.

Kausar, A.; Naeem, K.; Iqbal, M. ; Nazli, Z. ; Bhatti, N. Haq; Ashraf, A.; Nazir, A.; Kusuma, H. ; Khan, M. Kinetics, equilibrium and thermodynamics of dyes adsorption onto modified chitosan: a review, Zeitschrift für Physikalische Chemie, 2021.

Popa, S.; Radulescu-Grad, M.E. ; Perdivara, A. ; Mosoarca. G. Aspects regarding colour fastness and adsorption studies of a new azo-stilbene dye for acrylic resins. Sci Rep. 2021 15;11(1):5889.

.Fatombi, J.K; Idohou, E.A. ; Osseni, S.A. et al. Adsorption of Indigo Carmine from Aqueous Solution by Chitosan and Chitosan/Activated Carbon Composite: Kinetics, Isotherms and Thermodynamics Studies. Fibers Polym, 2019, 20, 1820–1832.