Evaluation of Osteocalcin and Some Biochemical Marker in Diabetes Mellitus Iraqi Women's patients with Osteoporosis

Authors

Abeer A. Jafer
Bushra H. Ali

DOI:

https://doi.org/10.30526/36.1.2984

Keywords:

Keywords: Osteocalcin, Osteoporosis, T2DM

Abstract

Diabetes mellitus is a set of metabolic diseases, the most prevalent of which is chronic hyperglycemia. The culprits include insulin synthesis, insulin action, or both. Osteoporosis is a progressive systemic skeletal disorder defined by decreased bone mass and micro architectural degeneration of bone tissue, resulting in increased bone fragility and fracture risk, according to the World Health Organization (WHO). The degree of Nervosa damage determines how much a diabetic patient's body has been compromised. The current study's goal is an estimation: Age, BMI, FBS, HbA1C, D3, ALP, Ca, P, and Osteocalcin in Iraqi T2DM Women's patients with and without Osteoporosis. Three vitamins are required for Osteocalcin biosynthesis: vitamin K for Gla formation, vitamin C for hydroxylation of Pro-9 to hydroxyproline, and vitamin D for Osteocalcin production stimulation. Vitamin D is known to function in calcium homeostasis and bone metabolism.

Osteocalcin is a hormone produced by osteoblasts and secreted into the extracellular matrix of bone and the bloodstream. It serves as a biological marker for bone formation. The work was classified into three groups. G1 (n= 40) is the control set that went to the Iraqi Ministry of Health's Endocrinology and Diabetes Center in Baghdad. G2 (n= 40) are patients with type 2 diabetes mellitus without Osteoporosis who visited the Endocrinology and Diabetes Center of the Iraqi Ministry of Health in Baghdad, and G3 (n= 40) are patients with type 2 diabetes Mellitus with Osteoporosis.

References

Al-Masoudi, Faris Ibrahim, Bushra H. Ali. Evaluation of Nesfatin–1 and Other Biochemical Markers in diabetic Neuropathy Iraqi patients before and after treatment with tegretol:Annals of the Romanian Society for Cell Biology ,2021, 9422-9429.

Salih, Nada Taha , Bushra H. Ali. Relation Study between Chromogranin a and Other Clinical Biomarker in Iraqi Children with Growth Hormone Deficiency Undergo Treated Via Recombinant Growth Hormone: Annals of the Romanian Society for Cell Biology 2021, 11072-11077.

Tan, Sin Yee, et al. Type 1 and 2 diabetes mellitus: A review on current treatment approach and gene therapy as potential intervention. Diabetes & metabolic syndrome: clinical research & reviews 2019,13,1, 364-372.

Rozenberg, Serge, et al. How to manage osteoporosis before the age of 50. Maturitas. 2020, 138,14-25.

Ha, J. Y., ; Choi, E. Y. Health perception, health concern, and health promotion behavior of the elders. Journal of Korean Gerontological Nursing . 2013,15,3, 277-85.

Hauschka, Peter V., et al. Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone. Physiological reviews .1989, 69,3,990-1047.

Levinger, Itamar, et al. Multifaceted interaction of bone, muscle, lifestyle interventions and metabolic and cardiovascular disease: role of osteocalcin. Osteoporosis International . 2017, 28,8, 2265-2273.

Mizokami, Akiko, Tomoyo Kawakubo-Yasukochi, and Masato Hirata. Osteocalcin and its endocrine functions. Biochemical pharmacology . 2017, 132, 1-8.

Zoch, Meredith L.;Thomas L. Clemens, ; Ryan C. Riddle. New insights into the biology of osteocalcin. Bone . 2016, 82 ,42-49.

Urano, Tomohiko, et al. Low serum osteocalcin concentration is associated with incident type 2 diabetes mellitus in Japanese women. Journal of Bone and Mineral Metabolism . 2018, 36,4 470-477.

Ferron, Mathieu, et al. Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proceedings of the National Academy of Sciences . 2008, 105,13 5266-5270.

Kanazawa, I., et al. Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus. Osteoporosis International . 2011,22,1, 187-194.

Lee, Ji Hyun, et al. Optimal body mass index for minimizing the risk for osteoporosis and type 2 diabetes. The Korean journal of internal medicine. 2020, 35,6 ,1432.

Roomi, Ali B. et al. Evaluation of Bone Mineral Density, Serum Osteocalcin, and Osteopontin Levels in Postmenopausal Women with Type 2 Diabetes Mellitus, with/without Osteoporosis. Journal of Osteoporosis 2022. 2022.

Park, Sung Keun, et al. Fasting glucose level and the risk of incident osteoporosis in the Koreans. Bone . 2021, 142 , 115690.

Fang, Lingna, et al. A cross-sectional study: an assessment of low muscle mass and osteoporosis in type 2 diabetes mellitus patients with a high glycated hemoglobin level. Therapeutic Advances in Chronic Disease . 2021, 12, 20406223211026762.

Kuchuk, Natalia O., et al. Vitamin D status, parathyroid function, bone turnover, and BMD in postmenopausal women with osteoporosis: global perspective. Journal of bone and mineral research . 2009, 24,4, 693-701.

Chen, Hailing, Jufen Li, and Qian Wang. Associations between bone-alkaline phosphatase and bone mineral density in adults with and without diabetes. Medicine . 2018, 97,17.

Siddapur, Priyanka Ramappa. A study to compare serum calcium level between diabetic and non-diabetic post-menopausal women with osteoporosis. Medicine . 2019, 97,17

Shakoor, Sadaf, et al. Prevalence of osteoporosis in relation to serum calcium and phosphorus in aging women. J Glob Innov Agric Soc Sci . 2014, 2,2 , 70-5

Raikou, Vaia D., Despina Kyriaki, ; Sotiris Gavriil. Importance of serum phosphate in elderly patients with diabetes mellitus. World Journal of Diabetes . 2020, 11,10 416.