Evaluation of CRP, IL-6 and Calprotectin in Saliva of Patients Suffering From Crohn’s Disease (CD)

Fadhl Abdullah Abed; Maha Adel Mahmood

doi:10.30526/36.4.3126

Authors

Fadhl Abdullah Abed Department of Basic Sciences College of Dentistry, University of Baghdad, Baghdad, Iraq
Maha Adel Mahmood Department of Basic Sciences College of Dentistry, University of Baghdad, Baghdad, Iraq

DOI:

https://doi.org/10.30526/36.4.3126

Keywords:

Salivary IL-6, CRP, Calprotectin, CD patients

Abstract

Inflammatory bowel disease (IBD) a chronic inflammatory condition of the gastrointestinal tract characterized by alternating episodes of clinical relapse and remission (Wallace, 2014), with Crohn's disease (CD) and ulcerative colitis (UC) being the two primary subtypes (Souza, 2016). The present study was achieved in Baghdad teaching hospital from November 2021 to June 2022 to prove if the diagnostic marker of Crohn’s disease (CD) (IL-6, CRP and Calprotectin( are rises in saliva as in sera and if there are significant difference in the levels of those markers between the Crohn’s disease (CD)group and control group.

The recent study was measured the levels of C-reactive protein (CRP), Interleukin-6 (IL6) and calprotectin in saliva of CD patients using ELISA method as those proteins has been previously proved to be elevated in sera of CD patient.

The results of the present study noted a significant mean differences in salivary levels of each of CRP,IL6 and calprotectin between CD group and the control group ( P < 0.05 ).

The current study was proved that there is a significant positive correlation between IL-6 levels and age in all study groups (CD and control) (P <0.05) and also a significant positive correlation was found between IL-6 and CRP in CD group patients (p<0.05) respectively.

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