Impact of Carbamazepine Treatment in Testicular Histology in Albino Mice (Mus musculus)

Main Article Content

Zainab Abd-Ali Sabr
Zainab Kareem

Abstract

Carbamazepine (CBZ) is an antiepileptic medication (AED) intended to treat epilepsy, although it is also used to treat psychiatric problems and neuropathic pain. CBZ use has been linked to male reproduction problems such as hormonal changes, sexual problems, and sperm quality loss in addition to its effect on the hypothalamic-pituitary-gonadal (HPG) axis. The present study aimed to check the potential consequences of carbamazepine on the histology of the testis. In this experiment, 24 adult males of Swiss albino mice were divided into four groups. The control group was gavaged with distilled water, and the others were treated with carbamazepine orally administered with 0.1 ml of a daily dose of concentrations (2.5, 5 and 10) mg/kg bw for 60 consecutive days. Several histological alterations were caused by the therapy in the testis, which included congestion, necrosis, edema, hemorrhage, shrinkage tubule, germ cell shedding, and amyloid.

Article Details

How to Cite
[1]
Sabr, Z.A.-A. and Kareem, Z. 2023. Impact of Carbamazepine Treatment in Testicular Histology in Albino Mice (Mus musculus). Ibn AL-Haitham Journal For Pure and Applied Sciences. 36, 4 (Oct. 2023), 40–50. DOI:https://doi.org/10.30526/36.4.3128.
Section
Biology

Publication Dates

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