Impact of Carbamazepine Treatment in Testicular Histology in Albino Mice  (Mus musculus)

Zainab Abd-Ali     Sabr; Zainab Kareem

doi:10.30526/36.4.3128

Authors

Zainab Abd-Ali Sabr Department of Biology College of Science for Women, University of Baghdad, Baghdad, Iraq
Zainab Kareem Department of biology , College of Science for Women , University of Baghdad, Baghdad, Iraq

DOI:

https://doi.org/10.30526/36.4.3128

Keywords:

Carbamazepine , testis , germ cells , Leydig cells, edema, necrosis

Abstract

Carbamazepine (CBZ) is an antiepileptic medication (AED) intended to treat epilepsy, although it is also used to treat psychiatric problems and neuropathic pain. CBZ use has been linked to male reproduction problems such as hormonal changes, sexual problems, and sperm quality loss in addition to its effect on the hypothalamic-pituitary-gonadal (HPG) axis. The present study aimed to check the potential consequences of carbamazepine on the histology of the testis. In this experiment, 24 adult males of Swiss albino mice were divided into four groups. The control group was gavaged with distilled water, and the others were treated with carbamazepine orally administered with 0.1 ml of a daily dose of concentrations (2.5, 5 and 10) mg/kg bw for 60 consecutive days. Several histological alterations were caused by the therapy in the testis, which included congestion, necrosis, edema, hemorrhage, shrinkage tubule, germ cell shedding, and amyloid.

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