Synthesis and Spectral Study of New Guanine Derivative (N-((6-Oxo-6,9-Dihydro-1H-Purin-2-yl)Carbamothioyl)Propionamide) and its Complexes with Some Metals Ion

Authors

Abdullah Sh. Abdullah Alani Directorate of Institutional Development and Government Coordination, Iraqi Ministry of Education, Baghdad, Iraq https://orcid.org/0000-0002-4820-0859
Basima Muhsen Sarhan Department of Chemistry, College of Education for Pure Science Ibn Al–Haitham, University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0003-3813-5982
Vishwa Deepak Tripathi Department of Chemstry, C.M. Science College, Lalit Narayan Mithila University, Darbhanga, Bihar, India https://orcid.org/0000-0003-2802-0292

DOI:

https://doi.org/10.30526/37.2.3313

Keywords:

Guanine, propionyl chloride, isothiocyanate, coordination complexes, organometallic compounds.

Abstract

This study included the preparation and characterization of the new guanine derivative (N-((6-oxo-6,9-dihydro-1H-purin-2-yl)carbamothioyl)propionamide), with an exciting chemical structure. The guanine part is a bicyclic heterocyclic base that is connected to a carbamothioyl group by a propionamide linker. This nitrogenous base derivative is prepared in two steps: The first step involves the synthesis of propionyl isothiocyanate from the reaction of propionyl chloride with ammonium thiocyanate in acetone. In contrast, the second step consists of the reaction of ammonium thiocyanate with guanine to obtain the ligand. The study also includes the preparation of new complexes of metal ions (Mn⁺², Co⁺², Ni⁺², Cu⁺², Zn⁺², Cd⁺², and Pd⁺²) with a prepared guanine derivative. The ligand and complexes were characterized by using infrared spectra, ultraviolet-visible spectra, ¹H-N.M.R., ¹³C-N.M.R. spectra, and elemental analysis (C.H.N.S.): molar conductivity measurement, magnetic susceptibility, atomic absorption, and melting point. The results of these studies showed that general formulas for these complexes were given [MCl₂(O.P.P.)₂], M = (Mn⁺², Co⁺², Ni⁺², Cu⁺², Zn⁺², Cd⁺², and Pd⁺²). It was found that the geometric shape of all the prepared complexes was an octahedron.

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