Assessment of Cartilage Acidic Protein 1 and other Biomarkers in Pre- and Post-Menopausal Iraqi Women with Osteoarthritis Disease

Noor Basil Ghanim; Bushra Faris  Hasan

doi:10.30526/37.4.3390

Authors

Noor Basil Ghanim Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq. https://orcid.org/0009-0009-4158-6128
Bushra Faris Hasan Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq. https://orcid.org/0000-0002-4766-6120

DOI:

https://doi.org/10.30526/37.4.3390

Keywords:

Cartilage acidic protein 1, follicle-stimulating hormone, luteinizing hormones, menopause, osteoarthritis

Abstract

Osteoarthritis (OA) is a degenerative disease that causes pain in humans' joints during movement, especially in the elderly and many women. Since cartilage plays a major destructive role during OA incidence, its chemical components can serve as a sensitive biomarker for diagnosing the onset and severity of OA disease. Cartilage acidic protein 1 (CRTAC1) is a critical component of the cartilage's extracellular matrix. We have aimed to test the sensitivity of CRTAC1 to the prognosis of OA disease in pre-and post-menopausal women with OA disease. The results showed that the levels of CRTAC1 in the serum of pre-and postmenopausal women with OA disease were significantly higher than those in control groups of the same age. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were also higher in these patients. Nonetheless, follicle-stimulating hormone (FSH), luteinizing hormones (LH), and testosterone were non-significantly changed in OA patients and the corresponding control group at both pre-and post-menopausal age. Pearson’s correlation was non-significant between CRTAC1 and the rest of the biomarkers. Finally, using CRTAC1 as a biomarker to predict when OA will start and how bad it will get has shown that it works well as a very sensitive and specific biomarker for the disease in women before and after menopause.

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