Assessment of Cartilage Acidic Protein 1 and other Biomarkers in Pre- and Post-Menopausal Iraqi Women with Osteoarthritis Disease
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Abstract
Osteoarthritis (OA) is a degenerative disease that causes pain in humans' joints during movement, especially in the elderly and many women. Since cartilage plays a major destructive role during OA incidence, its chemical components can serve as a sensitive biomarker for diagnosing the onset and severity of OA disease. Cartilage acidic protein 1 (CRTAC1) is a critical component of the cartilage's extracellular matrix. We have aimed to test the sensitivity of CRTAC1 to the prognosis of OA disease in pre-and post-menopausal women with OA disease. The results showed that the levels of CRTAC1 in the serum of pre-and postmenopausal women with OA disease were significantly higher than those in control groups of the same age. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were also higher in these patients. Nonetheless, follicle-stimulating hormone (FSH), luteinizing hormones (LH), and testosterone were non-significantly changed in OA patients and the corresponding control group at both pre-and post-menopausal age. Pearson’s correlation was non-significant between CRTAC1 and the rest of the biomarkers. Finally, using CRTAC1 as a biomarker to predict when OA will start and how bad it will get has shown that it works well as a very sensitive and specific biomarker for the disease in women before and after menopause.
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