Metoprolol Tartrate Drug Loading and Release from Prepared Mesoporous Silica; Kinetic of Adsorption and Release
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Abstract
Mesoporous silica was developed to transport metoprolol tartrate (MPT). The data obtained from the kinetic experiments of adsorption of 15 ppm of MPT drug at 293 K was fitted in the pseudo-first-order, pseudo-second-order, and intraparticle diffusion models. The results show that the adsorption process obeys the pseudo-first-order equation and the rate-controlling step, not just the intraparticle diffusion step. The MPT drug load onto mesoporous silica was 15.13 mg/g. The release profile shows that the MPT drug was about 55% released after 40 min when released in water, while in phosphate-buffered saline (PBS) media, the release reached 90% after 60 min at body temperature (37°C). Three kinetic release versions, including first-order, Kopcha, and Korsmeyer-Peppas, were used to fit the in vitro drug release data. The results indicate that the Korsmeyer-Peppas model provided the best fit. The predicted n values show that the release process for water and PBS pH 7.4 media is not Fickian.
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Garcia-Bennett, A.E. Synthesis, toxicology and potential of ordered mesoporous materials in nano medicine. Nano medicine, 2011, 6(5),867–877. https://doi: 10.2217/nnm.11.82.
Vallet-Regi, M.; Ramila, A.; del Real, R.P.; Perez-Pariente, J. A new property of MCM-41. Drug delivery system. Chem. Mater, 2001,13(2),308–311.
https://doi.org/10.1021/cm0011559.
Manzano, M.; Vallet‐Regí, M. Mesoporous silica nanoparticles for drug delivery. Adv. Funct.Mater, 2020,30(2),1902634. https://doi.org/10.1002/adfm.201902634.
Li, Z.; Zhang, Y.; Feng, N. Mesoporous silica nanoparticles: synthesis, classification, drug loading, pharmacokinetics, biocompatibility, and application in drug delivery. Expert opinion on drug delivery, 2019, 16(3),219-237. https://doi: 10.1080/17425247.2019.1575806.
Vallet-Regí, M.; Schüth, F.; Lozano, D.; Colilla, M.; Manzano, M. Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?. Chem. Soc. Rev., 2022, 51(13), 5365-5451. https://doi: 10.1039/d1cs00659b.
Andrade, G.F.; Soares, D.C.F.; Almeida, R.K.D.S.; Sousa, E.M.B. Mesoporous silica SBA-16 functionalized with alkoxysilane groups: Preparation, characterization, and release profile study. J. Nanomater, 2021, 2012,1687–4110. https://doi.org/10.1155/2021/816496.
Ambrogi, V.; Perioli, L.; Marmottini, F.; Accorsi, O.; Pagano, C.; Ricci, M.; Rossi, C. Role of mesoporous silicates on carbamazepine dissolution rate enhancement. Micropor. Mesopor. Mater., 2008, 113(1-3),445–452. https://doi:10.1016/j.micromeso.2007.12.003.
Eren, Z.S.; Tunçer, S.; Gezer, G.; Yildirim, L.T.; Banerjee, S.; Yilmaz, A. Improved solubility of celecoxib by inclusion in SBA-15mesoporous silica: Drug loading in different solvents and release. Micropor. Mesopor. Mater., 2019, 235, 211–223. https://doi:10.1016/j.micromeso.2019.08.014.
Charnay, C.; Bégu, S.; Tourné-Péteilh, C.; Nicole, L.; Lerner, D.A.; Devoisselle, J.M. Inclusion of ibuprofen in mesoporous templated silica: Drug loading and release property. Eur. J. Pharm. Biopharm., 2004, 57(3),533–540. https://doi: 10.1016/j.ejpb.2003.12.007
Limnell, T.; Santos, H.A.; Mäkilä, E.; Heikkilä, T.; Salonen, J.; Murzin, D.Y.; Kumar, N.; Laksonen, T.; Peltonen, L.; Hirvonen, J. Drug delivery formulations of ordered and nonordered mesoporous silica: comparison of three drug loading methods. J. Pharm. Sci., 2011, 100(8),3294–3306. https://doi: 10.1002/jps.22577
Abd-elbary, A.; El Nabarawi, M.A.; Hassen, D.H.; Taha, A.A. Inclusion and characterization of ketoprofen into different mesoporous silica nanoparticles using three loading methods. Int. J. Pharm. Pharm. Sci., 2014, 6(9),183–191.
https://journals.innovareacademics.in/index.php/ijpps/article/view/2014/9727.
Vadia, N.; Rajput, S. Study on formulation variables of methotrexate loaded mesoporous MCM-41 nanoparticles for dissolution enhancement. Eur. J. Pharm. Sci., 2012, 45(1-2),8–18. https://doi:10.1016/j.ejps.2011.10.016.
Guo, Z.; Liu, X.-M.; Ma, L.; Li, J.; Zhang, H.; Gao, Y.-P.; Yuan, Y. Effects of particle morphology, pore size and surface coating of mesoporous silica on Naproxen dissolution rate enhancement. Colloids Surf B Biointerfaces, 2021, 101, 228–235. https://doi: 10.1016/j.colsurfb.2020.06.026.
Ambrogi, V.; Perioli, L.; Marmottini, F.; Giovagnoli, S.; Esposito, M.; Rossi, C. Improvement of dissolution rate of piroxicam by inclusion into MCM-41 mesoporous silicate. Eur. J. Pharm. Sci., 2007, 32(3), 216–222. https://doi:10.1016/j.ejps.2007.07.005.
Martín, A.; García, R.A.; Karaman, D.S.; Rosenholm, J.M. Polyethyleneimine-functionalized large pore ordered silica materials for poorly water-soluble drug delivery. J. Mater. Sci., 2019, 49(3),1437–1447. https://doi:10.1007/s10853-013-7828-1.
Thomas, M.J.K.; Slipper, I.;Walunj, A.; Jain, A.; Favretto, M.E.; Kallinteri, P.; Douroumis, D. Inclusion of poorly soluble drugs in highly ordered mesoporous silica nanoparticles. Int. J. Pharm., 2010, 387(1-2), 272–277. https://doi:10.1016/j.ijpharm.2009.12.023.
Kareem, S.H. Magnetic mesoporous silica material (Fe3O4@ mSiO2) as adsorbent and delivery system for ciprofloxacin drug, IOP Conf. Ser.: Mater. Sci. Eng., 2020,871,012020.
https://doi:10.1088/1757-899X/871/1/012020.
Hussein, E.A.;Kareem, S.H. Mesoporous silica nanoparticles as a system for ciprofloxacin drug delivery; kinetic of adsorption and releasing. Baghdad Sci. J., 2021,18(2),357-365.
http://dx.doi.org/10.21123/bsj.2021.18.2.0357.
Ghedini, E.;Signoretto, M.;Pinna, F.; Crocellà, V.; Bertinetti, L.; Cerrato, G. Controlled release of metoprolol tartrate from nanoporous silica matrices., Micropor. Mesopor. Mat., 2010,132(1-2), 258-267. https://doi:10.1016/j.micromeso.2010.03.005
Lagergren, S. Zur theorie der sogenannten adsorption geloster stoffe. Kungliga svenska vetenskapsakademiens. Handlingar, 1898,24,1-39.
https://www.scirp.org/reference/ReferencesPapers?ReferenceID=1530542
Ho, Y.S.; McKay, G. Pseudo-second order model for sorption processes. Process Biochem., 1999, 34,451-465. https://doi.org/10.1016/S0032-9592(98)00112-5.
Hiawi, F.A.; Ali , I.H. Study the interaction adsorptive behavior of sunset yellow dye and loratadine drug: Kinetics and thermodynamics study. IHJPAS., 2023,36(1),196-186.
https://doi: https://doi.org/10.30526/36.1.2974.
Weber Jr, W.J.; Morris, J.C. Kinetics of adsorption on carbon from solution. J. San. Eng. Div. ASCE.1963,89(2),31-59. https://www.scirp.org/reference/referencespapers?referenceid=2080421.
Doke, K.M. ;Khan, E.M. Equilibrium, kinetic and diffusion mechanism of Cr (VI) adsorption onto activated carbon derived from wood apple shell. Arab. J. Chem., 2012, 10(2017),252-260. https://doi:10.1016/j.arabjc.2021.07.031
Hameed, B.H.; Mahmoud, D.K.; Ahmad, A.L. Equilibrium modeling and kinetic studies on the adsorption of basic dye by a low-cost adsorbent: Coconut (Cocos nucifera) bunch waste. J. Hazard. Mater., 2008, 158(1), 65-72. https://doi.org/10.1016/j.jhazmat.2008.01.034.
Cicily, J.R. Biomedical applications of mesoporous silica particles, doctoral dissertation, The University of Iowa: Iowa City, DC, 2017. https://doi: 10.17077/etd.837jo63c.
Mei, X.; Chen, D.;Li, N.;Xu, Q.; Ge, J.; Li, H.;Yang, B.; Xu, Y.; Lu, J. Facile preparation of coating fluorescent hollow mesoporous silica nanoparticles with pH-sensitive amphiphilic diblock copolymer for controlled drug release and cell imaging. Soft matter., 2012, 19(8),5309-5316.https://pubs.rsc.org/en/content/articlelanding/2012/sm/c2sm07320j.
Uribe Madrid, S.I.; Pal, U.; Kang, Y.S.; Kim, J.; Kwon, H.; Kim, J. Fabrication of Fe3O4@ mSiO2 core-shell composite nanoparticles for drug delivery applications. Nanoscale Res. Lett., 2015, 10,1-8. https://doi: 10.1186/s11671-015-0920-5.
Badran, M.M.; Alomrani, A.H.; Almomen, A.; Bin Jardan, Y.A.; Abou El Ela, A.E.S. Novel metoprolol-loaded chitosan-coated deformable liposomes in thermosensitive in situ gels for the management of glaucoma: A Repurposing Approach. Gels, 2022, 8(10),635.
https://doi.org/10.3390/gels8100635.
Heredia, N.S.; Vizuete, K.; Flores-Calero, M.; Pazmiño, V.K.; Pilaquinga, F.; Kumar, B.; Debut, A. Comparative statistical analysis of the release kinetics models for nanoprecipitated drug delivery systems based on poly (lactic-co glycolicacid). PLOS ONE, 2022, 17(3),e0264825. https://doi.org/10.1371/journal.pone.0264825.
Otalvaro, J.O.; Álvarez, T.R.; Gurovic, M.S.V.; Lassalle, V.; Agotegaray, M.; Avena, M.; Brigante, M. Magnetic mesoporous silica nanoparticles for drug delivery systems: Synthesis, characterization and application as norfloxacin carrier. J. Pharm. Sci., 2022, 111(10),2879-2887. https://doi: 10.1016/j.xphs.2022.05.024
Albayati, T.M.; Abd Alkadir, A.J. Synthesis and characterization of mesoporous materials as a carrier and release of prednisolone in drug delivery system. J Drug Deliv Sci Technol., 2019, 53,101-176. https://doi.org/10.1016/j.jddst.2019.101176.
Vora, C.; Patadia, R.; Mittal, K.; Mashru, R. Risk based approach for design and optimization of stomach specific delivery of rifampicin. Int. J. Pharm., 2013,455(1-2),169-181.
https://doi: 10.1016/j.ijpharm.2013.07.043.
Tariq, R.; Mammar, D.E. Synthesis, characterization and surface properties of nano-TiO2 using a novel leaf extracts. IHJPAS, 2023, 36(4),221-231. https://doi.org/10.30526/36.4.3161.