Synthesis and antimicrobial evaluation of new 1,3,4 – Thiadiazole Derivatives

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Iman F. Mustafa
Eman M. Hussain

Abstract

The amino thiadiazole [I] on treatment with aromatic aldehydes yielded Schiff bases [IIa-c] , which cyclized to thiazolidinone [IIIa-c] derivatives by reaction with thioglycolic acid .Reaction of carbon disulfide and methyl iodide with [I] gavedithiomethyl[IV] which on treatment with o-phenylenediamine gave the condensed N-Imidazolythiadiazolylamine [V] , However , reaction of [I] with phenylisocyanate and phenylisothiocyanate afforded the carbamideand carbothiamide derivatives[VI.VII]a-c. The structure of these compounds was characterized from their  melting point , FTIR spectroscopy and elementalanalysis

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How to Cite
Mustafa, I. F., & Hussain, E. M. (2017). Synthesis and antimicrobial evaluation of new 1,3,4 – Thiadiazole Derivatives. Ibn AL- Haitham Journal For Pure and Applied Sciences, 27(1), 297–305. Retrieved from https://jih.uobaghdad.edu.iq/index.php/j/article/view/395
Section
Chemistry