Synthesis and Study Biological Activity of Some New Isoxazoline and Pyrazoline derivatives

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Muna S. Al-Rawi
Jumbad H. Tomma
Rana M. Abdullah

Abstract

   This work involves synthesis of novel Schiff bases derivatives contining isoxazoline or pyrazoline units starting with chalcons . 4-Aminoacetophenone was reacted with 3-nitrobenzaldehyde in basic medium giving chalcone [I] by claisen-schemidt reaction. The chalcone [I]  was reacted with hydroxylamine hydrochloride giving isoxazoline [II]  in basic medium. The chalcone [I] could also react with hydrazitne hydrate to give pyrazoline [III]  . The novel Schiff bases with structural formula [IV] and [V] were prepared by the reaction of amino compounds ; isoxazoline [II] and pyrazolines [III] with p-substituted aldehydes or p-subsituted ketones, respectively in dry benzene using drops of glacial acetic acid as a catalyst with reflux. All the synthesized compounds have been characterized by melting points , FTIR and 1HMNR (of some of theme) spectroscopy. The biological activity of  all compounds was examined against antibacterial ; gram(+) and gram(-).

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How to Cite
[1]
Al-Rawi, M. S. et al. 2017. Synthesis and Study Biological Activity of Some New Isoxazoline and Pyrazoline derivatives. Ibn AL-Haitham Journal For Pure and Applied Sciences. 26, 1 (Apr. 2017), 208–217.
Section
Chemistry

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