Effect of CCl4 and Nigella sativa oil on histological changes of liver in the immature white Rats

Abstract

This study aimed to investigat the effect of Carbon tetrachloride CCl4 and Nigella
sativa oil on histological changes of liver. It was used only (20) immature male rats. to study
the effect of Carbon tetrachloride CCl4 and Nigella sativa oil on changes. The rats were
randomly divided into equal groups as follows. First group was injected intra dermally with
0.1 ml, normal saline (two times per weeks). This group was considered as control group .The
second group was injected intra dermally with (Carbon tetrachloride CCl4 ml / 100g ) of body
weight for ( two times per weeks was injected for (8weeks) . The third group It was orally
given 0.1 ml dose of Nigella sativa oil, it was injected for (8weeks).The fourth group was
treated with Carbon tetrachloride CCl4 and Nigella sativa oil in the same previous way.
There was clear effect for Carbon tetrachloride CCl4 on liver, it was caused infiltrative cells
presented by lymphocytes and phagocyte, liver cells defect; like edema, necrosis and
haemolysis in liver cells, it was found catalytic effect in treated group with Carbon
tetrachloride CCl4 and Nigella sativa oil liver, It appeared in normal appearance and like the
control group. It showed catalytic effect in treated groups with Carbon tetrachloride CCl4 and
Nigella sativa oil , and little negative in the liver.