Synthesis, Characterization and Effect of bis-1,3,4Oxadiazole Containing Glycine Moiety on the Activity of Some Transferase Enzymes.

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I. H. R. Tomi
A. H. J. Al-Qaisi
Z. H. J. Al-Qaisi

Abstract

  We described herein the synthesis of novel bis-1,3,4-oxadiazole containing glycine moiety. N-{5-[5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-yl-sulfanyl]-1,3,4-oxadiazole-2-yl-methyl}-4methoxybenzamide was fully characterized by elemental analysis, FT-IR and 1H NMR spectroscopy. Also this study was designed to show the effects of bis-oxadiazole compound on the activities of some transferase enzymes such as: GOT, GPT and γ-GT in sera. This compound demonstrated activation on GOT and GPT activities, inhibitory effects on the γ-GT activity. These effects increased with the increasing of the concentration of the compound. The causes of the increases and decreases in the enzymes activities are discussed

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How to Cite
Synthesis, Characterization and Effect of bis-1,3,4Oxadiazole Containing Glycine Moiety on the Activity of Some Transferase Enzymes. (2017). Ibn AL-Haitham Journal For Pure and Applied Sciences, 23(3), 190-204. https://jih.uobaghdad.edu.iq/index.php/j/article/view/915
Section
Chemistry

How to Cite

Synthesis, Characterization and Effect of bis-1,3,4Oxadiazole Containing Glycine Moiety on the Activity of Some Transferase Enzymes. (2017). Ibn AL-Haitham Journal For Pure and Applied Sciences, 23(3), 190-204. https://jih.uobaghdad.edu.iq/index.php/j/article/view/915