Synthesis and Spectral Investigation of Mixed Schiff Base and L-Leucine Complexes and their Biological Activity

Maysam Basem  Abdulsalam; Taghreed Hashim  AL-Noor; Aly  Abdou

doi:10.30526/39.2.4340

Authors

Maysam Basem Abdulsalam Department of Chemistry, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad, Baghdad, Iraq https://orcid.org/0009-0005-3630-8829
Taghreed Hashim AL-Noor Department of Chemistry, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0002-6761-7131
Aly Abdou Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524 Egypt https://orcid.org/0000-0002-5979-2650

DOI:

https://doi.org/10.30526/39.2.4340

Keywords:

Biological activity, L-Leucine, Schiff base, Sulfonamides, Transition metals

Abstract

In this study, transition complexes of Fe(III), Zn(II), La(III), Ce(III), and Pr(III) with a Schiff base ligand (L), which is derived from 3-hydroxybenzaldehyde and sulfamethoxazole, as the primary ligand, and L-Leucinate as a secondary ligand. The bonding mode of the Schiff base has been confirmed through a range of techniques, including infrared, UV-visible (UV-Vis), carbon and proton nuclear magnetic resonance spectroscopy, mass spectrometry, and elemental analysis. All complexes were characterized by elemental analysis, conductivity measurements, and spectroscopic techniques, including UV-Vis and Fourier transform infrared spectroscopy. A thorough discussion is provided on the structural and bonding features of the mixed ligand complexes formed from the Schiff base (L) and L-Leucine with ions [Fe (III), Zn(II), La(III), Ce(III), and Pr(III)], based on results from various research studies. Additionally, the antimicrobial activity of these complexes was evaluated against two Gram-positive and two Gram-negative bacterial strains. Furthermore, antifungal activity against Candida was evaluated, with tetracycline as the reference.

Author Biographies

Maysam Basem Abdulsalam, Department of Chemistry, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad, Baghdad, Iraq

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Taghreed Hashim AL-Noor, Department of Chemistry, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad, Baghdad, Iraq

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Aly Abdou, Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524 Egypt

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